Malarone is a prescription-only oral tablet used to prevent malaria. Malarone is a brand name, the active ingredients are Atovaquone and Proguanil. Atorvaquone and Proguanil are the generic version of Malarone. This medicine is effective in preventing patients from contracting malaria which is a fatal and life-threatening condition
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What is Atovaquone/Proguanil?
Atovaquone/Proguanil is used for the treatment and prevention of malaria. Malaria is a serious disease, at times fatal, caused by a parasite from a certain type of mosquito. The parasite enters the body through the bites of a mosquito. The parasites live in the body tissues such as the liver or red blood cells.
This medication may be combined with other medications such as primaquine to complete the treatment
Atovaquone/Proguanil belongs to the class of medications known as antimalarials.
How does Atovaquone/Proguanil work?
This combination medication works by killing P. falciparum, the parasite which causes malaria. Mosquito bites allow the entry of P. falciparum into the bloodstream and then live in the body tissues. This combination medication has proven effective where other antimalarial medications are not effective.
What are the benefits of using Atovaquone/Proguanil?
The main benefit of taking Atovaquone/Proguanil is the treatment or prevention of malaria by killing the parasites that cause the disease. This medication, alone or in combination with other medication, is effective in treating malaria where other medications failed. It is always important that you also take additional measures to prevent yourself from contracting malaria when abroad.
You should take one tablet every day at roughly the same time each day.
Atovaquone/Proguanil tablets need to be taken 1 – 2 days before entering an area where malaria is present and continued until 7 days after leaving the malaria area.
You should take Atovaquone/Proguanil tablets with or after food or milk.
Atovaquone/Proguanil remains effective with a moderate alcohol intake.
If you do experience side effects from Atovaquone/Proguanil they may include coughing, diarrhoea, dizziness, headache, loss of appetite, mouth sores, nausea, stomach pain, vomiting, or weakness. Atovaquone/Proguanil has a small risk of nausea, vomiting, diarrhoea, and skin rash as with all medicines.
A small number of medications are known to interact with Atovaquone/Proguanil, including Rifampicin, Rifabutin, Metoclopramide, Tetracycline, and Warfarin.
The effectiveness of Atovaquone has also been shown to be limited in those suffering from liver disease, feeding problems, diarrhoea, and malabsorption syndrome. For best absorption, it’s recommended to take Atovaquone/Proguanil with a meal or milky drink.
Active ingredients
Proguanil Hydrochloride 100mg
Atovaquone 250mg
The other ingredients are:
Tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30, sodium starch glycollate (Type A), magnesium stearate.
Tablet coating: hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and polyethylene glycol 8000.
Atovaquone and Proguanil 250mg/100mg tablets
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